|
| Interactions: | Antacids Comb.
Adverse Effect: Decreased famotidine effectiveness
Clinical Management: If an interaction is suspected, administer the antacid at least one to two hours after the famotidine dose.
Cefpodoxime
Adverse Effect: decreased cefpodoxime effectiveness.
Clinical Management: Alternative antibiotic therapy (eg, select another third generation cephalosporin or a second generation cephalosporin with similar activity) should be considered. If possible, switch to another anti-ulcer medication (eg, sucralfate) and take cefpodoxime at least two hours before the dose.
Itraconazole
Adverse Effect: loss of itraconazole efficacy
Clinical Management:Itraconazole should be administered with a cola beverage if the patient is receiving an H2 receptor antagonist, such as famotidine.
Ketoconazole
Adverse Effect: decreased ketoconazole effectiveness
Clinical Management: Concurrent administration of ketoconazole and famotidine is not recommended. If concurrent use cannot be avoided, famotidine should be taken at least two hours after ketoconazole. Because staggered administration may not be completely reliable, aggressively monitor these patients for continued antifungal efficacy.
Probenecid
Adverse Effect: Increased famotidine concentration
Clinical Management: Although the clinical significance of this interaction has not been established, a lower dosage of famotidine may be required to produce a therapeutic effect. Increases in the famotidine dose should be made cautiously and in small increments when probenecid is being coadministered.
Theophylline
Adverse Effect:Theophylline toxicity (nausea, vomiting, palpitations, seizures) |
|
|